Ads
related to: what is pde5 enzyme
Search results
Results From The WOW.Com Content Network
PDE5 is an enzyme that accepts cGMP and breaks it down. Sildenafil, vardenafil and tadalafil are inhibitors of this enzyme, which bind to the catalytic site of PDE5. Both inhibitors bind with high affinity and specificity, and cGMP-binding to the allosteric sites stimulates binding of PDE5 inhibitors at the catalytic site.
A phosphodiesterase type 5 inhibitor (PDE5 inhibitor) is a vasodilating drug that works by blocking the degradative action of cGMP-specific phosphodiesterase type 5 (PDE5) on cyclic GMP in the smooth muscle cells lining the blood vessels supplying various tissues.
A phosphodiesterase (PDE) is an enzyme that breaks a phosphodiester bond. Usually, phosphodiesterase refers to cyclic nucleotide phosphodiesterases, which have great clinical significance and are described below.
Like other ED medications, Cialis is a PDE5 inhibitor. It works by blocking the effects of PDE5, or cGMP-specific phosphodiesterase type 5 — an enzyme that’s responsible for controlling the ...
These medications, called Phosphodiesterase-5 inhibitors, or PDE5 inhibitors, ... The active ingredient in this medication is an enzyme that breaks down collagen forming within connective tissue ...
Viagra belongs to a class of drugs (medications that act similarly) called phosphodiesterase type 5 (PDE5) inhibitors. These medications work to stop the PDE5 enzyme, making it easier for blood to ...
The PDE5 enzyme has a molecular mass of 200 kDa and its active state is a homodimer. [21] PDE5 consists of monomers and each contains two major functional domains: the regulatory domain (R domain) which is located in the N-terminal portion of the protein and the catalytic domain (C domain) located in the more C-terminal portion of the protein ...
Phosphodiesterase-5. A phosphodiesterase inhibitor is a drug that blocks one or more of the five subtypes of the enzyme phosphodiesterase (PDE), thereby preventing the inactivation of the intracellular second messengers, cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) by the respective PDE subtype(s).
Ad
related to: what is pde5 enzyme