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Parafollicular cells, also called C cells, are neuroendocrine cells in the thyroid. They are called C cells because the primary function of these cells is to secrete calcitonin. [1] They are located adjacent to the thyroid follicles and reside in the connective tissue. These cells are large and have a pale stain compared with the follicular cells.
[10] [11] The parathyroid gland is located beside the thyroid gland in the neck, below and in front of the larynx and above the trachea. It is composed of four glands in total that monitor blood calcium levels via the calcium sensing receptors, a g-coupled protein receptor. [12] The parathyroid glands main role is calcium homeostasis.
The parathyroid glands are variable in number: three or more small glands, [5] and can usually be located on the posterior surface of the thyroid gland. [5] Occasionally, some individuals may have six, eight, or even more parathyroid glands. [3] Rarely, the parathyroid glands may be within the thyroid gland itself, the chest, or even the thymus ...
The fourth pharyngeal pouch later encounters the developing thyroid gland and migrates to the upper poles of the thyroid lobes. At 14 weeks of gestation, the parathyroid glands begin to enlarge from 0.1 mm in diameter to approximately 1 – 2 mm at birth.
There are many variants in the size and shape of the thyroid gland, and in the position of the embedded parathyroid glands. [5] Sometimes there is a third lobe present called the pyramidal lobe. [5] When present, this lobe often stretches up to the hyoid bone from the thyroid isthmus and may be one to several divided lobes. [4]
[1] The hypothalamic–pituitary–thyroid axis (HPT axis for short, a.k.a. thyroid homeostasis or thyrotropic feedback control) is part of the neuroendocrine system responsible for the regulation of metabolism and also responds to stress. As its name suggests, it depends upon the hypothalamus, the pituitary gland, and the thyroid gland.
Thyroid disease is a medical condition that affects the structure and/or function of the thyroid gland. The thyroid gland is located at the front of the neck and produces thyroid hormones [1] that travel through the blood to help regulate many other organs, meaning that it is an endocrine organ. These hormones normally act in the body to ...
The parathyroid glands, of which there are 4–6, are found on the back of the thyroid glands, and secrete parathyroid hormone, [2] This causes an increase in blood calcium levels by targeting bone, the intestine, and the kidneys. The parathyroid hormone is the antagonist of calcitonin. Parathyroid hormone release is triggered by falling blood ...