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The area under the effect curve (AUEC) is an integral of the effect of a drug over time, estimated as a previously-established function of concentration. It was proposed to be used instead of AUC in animal-to-human dose translation, as computer simulation shows that it could cope better with half-life and dosing schedule variations than AUC.
The absolute bioavailability is the dose-corrected area under curve (AUC) non-intravenous divided by AUC intravenous. The formula for calculating the absolute bioavailability, F, of a drug administered orally (po) is given below (where D is dose administered).
The peak is "well-sampled", so that less than 10% of the area or volume under the peak (area if a 1D Gaussian, volume if a 2D Gaussian) lies outside the measurement region. The width of the peak is much larger than the distance between sample locations (i.e. the detector pixels must be at least 5 times smaller than the Gaussian FWHM).
Total drug exposure is most often estimated by area under the curve (AUC) methods, with the trapezoidal rule (numerical integration) the most common method. Due to the dependence on the length of x in the trapezoidal rule, the area estimation is highly dependent on the blood/plasma sampling schedule. That is, the closer time points are, the ...
A 2016 Science paper reports that the trapezoid rule was in use in Babylon before 50 BCE for integrating the velocity of Jupiter along the ecliptic. [1]In 1994, a paper titled "A Mathematical Model for the Determination of Total Area Under Glucose Tolerance and Other Metabolic Curves" was published, only to be met with widespread criticism for rediscovering the Trapezoidal Rule and coining it ...
This probability is given by the integral of this variable's PDF over that range—that is, it is given by the area under the density function but above the horizontal axis and between the lowest and greatest values of the range. The probability density function is nonnegative everywhere, and the area under the entire curve is equal to 1.
For instance, in the latter, Simpson's 3rd rule is used to find the volume between two co-ordinates. To calculate the entire area / volume, Simpson's first rule is used. [7] Simpson's rules are used by a ship's officers to check that the area under the ship's GZ curve complies with IMO stability criteria.
Approximating the area under the curve y = x 2 over [0, 2] using the right Riemann sum. Notice that because the function is monotonically increasing, the right Riemann sum will always overestimate the area contributed by each term in the sum (and do so maximally).