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The CD nomenclature was proposed and established in the 1st International Workshop and Conference on Human Leukocyte Differentiation Antigens (HLDA), held in Paris in 1982. [4] [5] This system was intended for the classification of the many monoclonal antibodies (mAbs) generated by different laboratories around the world against epitopes on the surface molecules of leukocytes (white blood cells).
CD48 is a human protein encoded by the CD48 gene. It is a universal cell membrane molecule present on all leukocytes. CD49a: Integrin alpha 1 subunit. CD49b: Very late antigen (VLA) alpha 2 chain; found on platelets and activated B and T cells. CD49c: Very late antigen (VLA) alpha 3 chain; found on nonhematopoietic bone marrow cells.
Schematic representation of CD4 receptor.. Like many cell surface receptors/markers, CD4 is a member of the immunoglobulin superfamily.. It has four immunoglobulin domains (D 1 to D 4) that are exposed on the extracellular surface of the cell:
941 12519 Ensembl ENSG00000121594 ENSMUSG00000075122 UniProt P33681 Q00609 RefSeq (mRNA) NM_005191 NM_009855 NM_001359898 RefSeq (protein) NP_005182 NP_033985 NP_001346827 Location (UCSC) Chr 3: 119.52 – 119.56 Mb Chr 16: 38.28 – 38.32 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The Cluster of differentiation 80 (also CD80 and B7-1) is a B7, type I membrane protein in the ...
CD163 (Cluster of Differentiation 163) is a protein that in humans is encoded by the CD163 gene. [5] CD163 is the high affinity scavenger receptor for the hemoglobin-haptoglobin complex [6] and in the absence of haptoglobin - with lower affinity - for hemoglobin alone. [7]
CD47 (Cluster of Differentiation 47) also known as integrin associated protein (IAP) is a transmembrane protein that in humans is encoded by the CD47 gene.CD47 belongs to the immunoglobulin superfamily [5] and partners with membrane integrins and also binds the ligands thrombospondin 1 (TSP-1) and signal-regulatory protein alpha (SIRPα). [6]
CD1 (cluster of differentiation 1) is a family of glycoproteins expressed on the surface of various human antigen-presenting cells.CD1 glycoproteins are structurally related to the class I MHC molecules, however, in contrast to MHC class 1 proteins, they present lipids, glycolipids and small molecules antigens, from both endogenous and pathogenic proteins, to T cells and activate an immune ...
CD96 is a transmembrane glycoprotein that has three extracellular immunoglobulin-like domains and is expressed by all resting human and mouse NK cells. CD96 main ligand is CD155 . CD 96 has approximately 20% homology with CD226 and competed for binding to CD155 with CD226.