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CD1a-restricted T cells are unique in the way that their TCR can directly recognize the CD1a molecule without corecognition of a lipid antigen. Self-reactive CD1b-restricted T cells can acquire the phenotype of T helper 17 (T H 17) cells and recruit neutrophils. CD1b is expressed at high levels on myeloid dendritic cells in blood and in tissues ...
CD1a self-reactive T cells were found in the blood of healthy individuals. [8] These cells express skin-homing receptors and produce interleukin 22 after binding CD1a on Langerhans cells. CD1a binds many endogenous lipids found in skin-oil and is able to activate T-cells even with ligands that lack a hydrophilic part, e.g. squalene. [2] [3]
CD1a (Cluster of Differentiation 1a) is a human protein encoded by the CD1A gene. [3] This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of ...
CD1a (Cluster of Differentiation 1a), or T-cell surface glycoprotein CD1a, is a human protein encoded by the CD1A gene. An antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. CD1b: T-cell surface glycoprotein CD1b.
CD1 (cluster of differentiation 1) is a family of glycoproteins expressed on the surface of various human antigen-presenting cells.CD1 glycoproteins are structurally related to the class I MHC molecules, however, in contrast to MHC class 1 proteins, they present lipids, glycolipids and small molecules antigens, from both endogenous and pathogenic proteins, to T cells and activate an immune ...
There, degradation and antigen processing for presentation to T-cells take place. For instance, langerin binds lipoarabinomannans of mycobacteria and inside the Birbeck granules, it contributes to the binding of the antigen to CD1a molecule.
The CD nomenclature was proposed and established in the 1st International Workshop and Conference on Human Leukocyte Differentiation Antigens (HLDA), held in Paris in 1982. [4] [5] This system was intended for the classification of the many monoclonal antibodies (mAbs) generated by different laboratories around the world against epitopes on the surface molecules of leukocytes (white blood cells).
T cells are one of the important types of white blood cells of the immune system and play a central role in the adaptive immune response. T cells can be distinguished from other lymphocytes by the presence of a T-cell receptor (TCR) on their cell surface. T cells are born from hematopoietic stem cells, [1] found in the bone marrow.