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Dilated submucosal veins are the most prominent histologic feature of esophageal varices. The expansion of the submucosa leads to elevation of the mucosa above the surrounding tissue, which is apparent during endoscopy and is a key diagnostic feature. Evidence of recent variceal hemorrhage includes necrosis and ulceration of the mucosa.
Both of these factors lead to obstruction or compression of the submucosal ducts of the esophagus, leading to the formation of the pseudodiverticulae. [1] Autopsy specimens of individuals with esophageal intramucosal pseudodiverticulosis have confirmed that the flask-like openings are indeed dilated submucosal glands. [ 3 ]
Intestinal varices are dilated submucosal veins in the intestine. [ citation needed ] One treatment includes a transjugular intrahepatic portosystemic shunt . [ 1 ]
Gastric varices are dilated submucosal veins in the lining of the stomach, which can be a life-threatening cause of bleeding in the upper gastrointestinal tract.They are most commonly found in patients with portal hypertension, or elevated pressure in the portal vein system, which may be a complication of cirrhosis.
Symptoms are thought to arise from transient abnormalities in the blood vessels of the brain. [1] In some cases, it may be associated with childbirth, vasoactive or illicit drug use, or complications of pregnancy. [1] If it occurs after delivery it may be referred to as postpartum cerebral angiopathy.
The pathophysiology of cranial venous outflow obstruction involves the disruption of normal venous drainage from the brain. Cerebral veins play a crucial role in draining brain interstitial fluid (ISF), and their significance has been linked in various neurological conditions. [1] It can be caused by extrinsic or intrinsic anomalies. [7]
Perivascular spaces may be enlarged to a diameter of five millimeters in healthy humans and do not imply disease. When enlarged, they can disrupt the function of the brain regions into which they project. [5] Dilation can occur on one or both sides of the brain. [7] Dilated perivascular spaces are categorized into three types: [7]
Anorectal varices are collateral submucosal blood vessels dilated by backflow in the veins of the rectum. [1] Typically this occurs due to portal hypertension which shunts venous blood from the portal system through the portosystemic anastomosis present at this site into the systemic venous system .