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Transcriptional repressor CTCF also known as 11-zinc finger protein or CCCTC-binding factor is a transcription factor that in humans is encoded by the CTCF gene. [ 5 ] [ 6 ] CTCF is involved in many cellular processes, including transcriptional regulation , insulator activity, V(D)J recombination [ 7 ] and regulation of chromatin architecture.
Moreover, CTCF and cohesin play important roles in determining TADs and enhancer-promoter interactions. The result shows that the orientation of CTCF binding motifs in an enhancer-promoter loop should be facing to each other in order for the enhancer to find its correct target.
CTCF forms methylation-sensitive insulators that regulate X-chromosome inactivation. Transcriptional repressor CTCFL (this protein) is a paralog of CTCF and appears to be expressed primarily in the cytoplasm of spermatocytes, unlike CTCF which is expressed primarily in the nucleus of somatic cells. CTCF and CTCFL are normally expressed in a ...
Excel for the web is a free lightweight version of Microsoft Excel available as part of Office on the web, which also includes web versions of Microsoft Word and Microsoft PowerPoint. Excel for the web can display most of the features available in the desktop versions of Excel, although it may not be able to insert or edit them.
Power Pivot, formerly known as PowerPivot (without spacing), is a self-service business intelligence feature of Microsoft Excel which facilitates the creation of a tabular model to import, relate, and analyze data from a variety of sources.
The closed-loop transfer function is measured at the output. The output signal can be calculated from the closed-loop transfer function and the input signal. Signals may be waveforms, images, or other types of data streams. An example of a closed-loop block diagram, from which a transfer function may be computed, is shown below:
In bacteria, the coding regions typically take up 88% of the genome. [1] The remaining 12% does not encode proteins, but much of it still has biological function through genes where the RNA transcript is functional (non-coding genes) and regulatory sequences, which means that almost all of the bacterial genome has a function. [1]
In documentation and instructional design, tutorials are teaching-level documents that help the learner progress in skill and confidence. [7] Tutorials can take the form of a screen recording (), a written document (either online or downloadable), interactive tutorial, or an audio file, where a person will give step by step instructions on how to do something.