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Guaifenesin is used in combination with, for example, ketamine, since guaifenesin does not provide analgesia or produce unconsciousness. [26] [27] In horses, the drug's biological half-life is 77 minutes. Premedication with xylazine (1.1 mg/kg) can reduce the dose required from 163 mg/kg (in geldings) to just 88 mg/kg. [27]
Guaifenesin/codeine is a fixed-dose combination cold medicine used for the treatment of cough. [1] It contains guaifenesin, an expectorant; and codeine, as the phosphate, an opioid antitussive. [1] It is taken by mouth. [1] It was approved for medical use in the United States in 2006. [1]
"Strength" is defined as analgesic potency relative to oral morphine. Tolerance , sensitization , cross-tolerance , metabolism , and hyperalgesia may be complex factors in some individuals. Interactions with other drugs , food and drink , and other factors may increase or decrease the effect of certain analgesics and alter their half-life.
Guaifenesin protocol is an unapproved treatment for fibromyalgia suggested in the 1990s by R. Paul St. Amand, M.D. The protocol involves three parts: titrating the guaifenesin dosage, avoiding salicylates , and following a low-carbohydrate diet if the patient is hypoglycemic .
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The third and fourth plateaus (7.5 mg/kg and over) cause profound alterations in consciousness, and users often report out-of-body experiences or temporary psychosis. [ 15 ] [ 16 ] This results in a sort of flanging (speeding up and/or slowing down) of sensory input, which is another characteristic effect of recreational use.