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Genes & Diseases is a bimonthly peer-reviewed open access medical journal covering medical genetics. It is published by Elsevier on behalf of Chongqing Medical University in alliance with the Association of Chinese Americans in Cancer Research .
Annual Review of Genomics and Human Genetics; European Journal of Human Genetics; Genetica; Genetics; Genome; Genome Biology; Genome Research; Heredity; Human Genomics and Proteomics; Nature Reviews Genetics; Nucleic Acids Research; PLOS Genetics; Somatic Cell and Molecular Genetics; Trends in Genetics
The optimality hypothesis states too much variability in the MHC can result in a failure of T-cells to distinguish themselves non-selves, and thereby increase the risk of autoimmune disease. This would confer greater fitness to individuals without a large degree MHC diversity. [6] [13] Autoimmune diseases are associated with MHC loci. In humans ...
Most focus on severe genetic disorders, including immunodeficiencies, haemophilia, thalassaemia, and cystic fibrosis. Such single gene disorders are good candidates for somatic cell therapy. The complete correction of a genetic disorder or the replacement of multiple genes is not yet possible. Only a few of the trials are in the advanced stages.
Cell is a peer-reviewed scientific journal publishing research papers across a broad range of disciplines within the life sciences. [1] Areas covered include molecular biology, cell biology, systems biology, stem cells, developmental biology, genetics and genomics, proteomics, cancer research, immunology, neuroscience, structural biology, microbiology, virology, physiology, biophysics, and ...
The central role of DNA damage and epigenetic defects in DNA repair genes in carcinogenesis. DNA damage is considered to be the primary cause of cancer. [17] More than 60,000 new naturally-occurring instances of DNA damage arise, on average, per human cell, per day, due to endogenous cellular processes (see article DNA damage (naturally occurring)).
Random transposition occurs, inserting the reporter gene randomly. The insertion tends to occur near actively transcribed genes, as this is where the chromatin structure is loosest, so the DNA most accessible. Grow flies and cross to remove genetic variation between the cells of the organism (see above). Look for flies expressing the reporter gene.
Transdifferentiation, also known as lineage reprogramming, [1] is the process in which one mature somatic cell is transformed into another mature somatic cell without undergoing an intermediate pluripotent state or progenitor cell type. [2]