Search results
Results From The WOW.Com Content Network
Copy number analysis is the process of analyzing data produced by a test for DNA copy number variation in an organism's sample. One application of such analysis is the detection of chromosomal copy number variation that may cause or may increase risks of various critical disorders.
Copy number variation (CNV) is a phenomenon in which sections of the genome are repeated and the number of repeats in the genome varies between individuals. [1] Copy number variation is a type of structural variation: specifically, it is a type of duplication or deletion event that affects a considerable number of base pairs. [2]
Multiplex ligation-dependent probe amplification (MLPA) is a variation of the multiplex polymerase chain reaction that permits amplification of multiple targets with only a single primer pair. [1] It detects copy number changes at the molecular level, and software programs are used for analysis.
CNVseq detects copy number variations supported on a statistical model derived from array-comparative genomic hybridization. Sequences alignment are performed by BLAT, calculations are executed by R modules and is fully automated using Perl. There are few other bioinformatics tools that can call CNA from RNA-Seq. [113]
Many biotechnology applications utilize mutated plasmids that replicate to high copy number. For example, pBR322 is a medium copy number plasmid (~20 copies/cell) from which several high copy number cloning vectors (>100 copies/cell) have been derived by mutagenesis, such as the well known pUC series. [1] This delivers the convenience of high ...
A simple link budget equation looks like this: Received power (dBm) = transmitted power (dBm) + gains (dB) − losses (dB) Power levels are expressed in , Power gains and losses are expressed in decibels (dB), which is a logarithmic measurement, so adding decibels is equivalent to multiplying the actual power ratios.
If the average number of nearest neighbors per transmitted bit () is equal to one, the effective coding gain () is approximately equal to the nominal coding gain ().
Paul Voigt patented a negative feedback amplifier in January 1924, though his theory lacked detail. [4] Harold Stephen Black independently invented the negative-feedback amplifier while he was a passenger on the Lackawanna Ferry (from Hoboken Terminal to Manhattan) on his way to work at Bell Laboratories (located in Manhattan instead of New Jersey in 1927) on August 2, 1927 [5] (US Patent ...