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Salvage therapy, in this context, is the attempt to contain the replicating HIV once the usual line of treatments have been exhausted. [4] When at least one regimen containing protease inhibitors has failed in a patient, the subsequent attempts to treat the HIV infection may be referred to as salvage therapy. [5]
Leronlimab (codenamed PRO 140) is a humanized monoclonal antibody targeted against the CCR5 receptor found on T lymphocytes of the human immune system.It is being investigated as a potential therapy in the treatment of triple negative breast cancer [1] and HIV infection.
It works by inhibiting the enzyme reverse transcriptase that HIV uses to make DNA and therefore decreases replication of the virus. [6] Zidovudine was first described in 1964. [7] It was resynthesized from a public-domain formula by Burroughs Wellcome. [8] It was approved in the United States in 1987 and was the first treatment for HIV.
The alpha interferon, named "Kemron" for this use, was a drug used to treat cancer in much greater doses. [2] In 1993, Professor Arthur Obel, a Kenyan scientist, claimed that Kemron and another drug called Pearl Omega could cure HIV/AIDS. Kemron was later proved to be ineffective and Pearl Omega had very few positive outcomes.
A Unique Approach to Infectious Disease and Cancer Treatment. Preclinical studies demonstrated that Indaptus’ Decoy bacteria—which are attenuated and killed bacteria designed to stimulate the immune system—produced significant single-agent activity in standard models of chronic HBV and HIV infections.
The human immunodeficiency virus (HIV) [8] [9] [10] is a retrovirus [11] that attacks the immune system.It is a preventable disease. [5] It can be managed with treatment and become a manageable chronic health condition. [5]
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