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Protein folding problem: Is it possible to predict the secondary, tertiary and quaternary structure of a polypeptide sequence based solely on the sequence and environmental information? Inverse protein-folding problem: Is it possible to design a polypeptide sequence which will adopt a given structure under certain environmental conditions?
A strong base is a basic chemical compound that can remove a proton (H +) from (or deprotonate) a molecule of even a very weak acid (such as water) in an acid–base reaction. Common examples of strong bases include hydroxides of alkali metals and alkaline earth metals, like NaOH and Ca(OH) 2, respectively. Due to their low solubility, some ...
In chemistry, an acid–base reaction is a chemical reaction that occurs between an acid and a base.It can be used to determine pH via titration.Several theoretical frameworks provide alternative conceptions of the reaction mechanisms and their application in solving related problems; these are called the acid–base theories, for example, Brønsted–Lowry acid–base theory.
2-tert-Butyl-1,1,3,3-tetramethylguanidine is an organic base, also known as Barton's base. It is named after Nobel Prize-winning British chemist Derek Barton . Barton and his assistants prepared a series of guanidines with steric hindrance in 1982; in this case five alkyl groups : four methyl groups and one tert -butyl group .
For example, aqueous perchloric acid (HClO 4), aqueous hydrochloric acid (HCl) and aqueous nitric acid (HNO 3) are all completely ionized, and are all equally strong acids. [ 3 ] Similarly, when ammonia is the solvent, the strongest acid is ammonium (NH 4 + ), thus HCl and a super acid exert the same acidifying effect.
Lithium diisopropylamide (commonly abbreviated LDA) is a chemical compound with the molecular formula LiN(CH(CH 3) 2) 2.It is used as a strong base and has been widely utilized due to its good solubility in non-polar organic solvents and non-nucleophilic nature.
a strong base; deprotonates ketones and esters to generate enolate derivative Sodium borohydride: a versatile reducing agent; converts ketones and aldehydes to alcohols Sodium chlorite: in organic synthesis, used for the oxidation of aldehydes to carboxylic acids Sodium hydride: a strong base used in organic synthesis Sodium hydroxide
An example of a weak base is ammonia. It does not contain hydroxide ions, but it reacts with water to produce ammonium ions and hydroxide ions. [4] The position of equilibrium varies from base to base when a weak base reacts with water. The further to the left it is, the weaker the base. [5]