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2. Docetaxel - Wikipedia

   en.wikipedia.org/wiki/Docetaxel

   Use during pregnancy may harm the baby. [6] Docetaxel is in the taxane family of medications. [9] It works by disrupting the normal function of microtubules and thereby stopping cell division. [6] Docetaxel was patented in 1986 and approved for medical use in 1995. [10] It is on the World Health Organization's List of Essential Medicines. [11]

3. TCH (chemotherapy) - Wikipedia

   en.wikipedia.org/wiki/TCH_(chemotherapy)

   TCH is a chemotherapy regimen consisting of Taxotere (docetaxel), carboplatin and Herceptin (trastuzumab), which is used to treat breast cancer. References [ edit ]

4. Taxane - Wikipedia

   en.wikipedia.org/wiki/Taxane

   Mechanism of action of taxanes. The principal mechanism of action of the taxane class of drugs is the disruption of microtubule function. Microtubules are essential to cell division, and taxanes stabilize GDP-bound tubulin in the microtubule, thereby inhibiting the process of cell division as depolymerization is prevented.

5. Breast cancer chemotherapy - Wikipedia

   en.wikipedia.org/wiki/Breast_cancer_chemotherapy

   By conducting a meta-analysis of four large breast cancer trials including nearly 3,000 patients, the researchers have discovered that an abnormality on chromosome 17, called CEP17, is associated with a worse outcome for patients, but also that its presence is a highly significant indicator that the tumor will respond to anthracyclines.

6. Indication (medicine) - Wikipedia

   en.wikipedia.org/wiki/Indication_(medicine)

   The opposite of an indication is a contraindication, [4] a reason to withhold a certain medical treatment because the risks of treatment clearly outweigh the benefits. In the United States, indications for prescription drugs are approved by the FDA. Indications are included in the Indications and Usage section of the Prescribing Information.

7. PD-1 and PD-L1 inhibitors - Wikipedia

   en.wikipedia.org/wiki/PD-1_and_PD-L1_inhibitors

   Use of an inhibitor that blocks the interaction of PD-L1 with the PD-1 receptor can prevent the cancer from evading the immune system in this way. [9] Several PD-1 and PD-L1 inhibitors are being trialled within the clinic for use in advanced melanoma, non-small cell lung cancer, renal cell carcinoma, bladder cancer and Hodgkin lymphoma, amongst ...