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Topical nicotinamide and topical zinc are safe, however, there are no FDA pregnancy category ratings. [27] [28] Topical salicylic acid and topical dapsone are classified as FDA pregnancy category C. [23] [28] Acne medications to avoid during pregnancy include oral isotretinoin and topical tazarotene as there have been reports of birth defects.
One characteristic of the FDA definitions of the pregnancy categories is that the FDA requires a relatively large amount of high-quality data on a pharmaceutical for it to be defined as Pregnancy Category A. As a result of this, many drugs that would be labelled as safe in other countries are allocated to Category C by the FDA.
It is unclear if it is safe for use in pregnancy. [6] Chlorpromazine was developed in 1950 and was the first antipsychotic on the market. [7] [8] It is on the World Health Organization's List of Essential Medicines. [9] [10] Its introduction has been labeled as one of the great advances in the history of psychiatry.
It is a recommended treatment in pregnancy and appears to be safe for the baby. [4] [5] The World Health Organization; however, recommends waiting until after pregnancy for treatment when feasible. [2] It is made from 4-methyl-piperazine. [6] Diethylcarbamazine was discovered in 1947 [7] by Yellapragada Subbarow.
Nortriptyline may cause problems if taken during pregnancy. [8] Use during breastfeeding appears to be relatively safe. [7] It is a tricyclic antidepressant (TCA) and is believed to work by altering levels of serotonin and norepinephrine. [8] Nortriptyline was approved for medical use in the United States in 1964. [8]
It is relatively safe for use during pregnancy and breastfeeding. [2] [4] Cefazolin is in the first-generation cephalosporin class of medication and works by interfering with the bacteria's cell wall. [2] Cefazolin was patented in 1967 and came into commercial use in 1971. [5] [6] It is on the World Health Organization's List of Essential ...
WASHINGTON (AP) — The maker of the only U.S. drug intended to prevent premature births is making a last-ditch effort […] The post FDA pushes to remove pregnancy drug, company pushes back ...
The actual definitions of the pregnancy categories are copied verbatim from the FDA regulations (which are in the public domain). Reference to some of the history: Sannerstedt R, Lundborg P, Danielsson BR, Kihlstrom I, Alvan G, Prame B, Ridley E. "Drugs during pregnancy: an issue of risk classification and information to prescribers."