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The exception is when neomycin is included, in small quantities, as a preservative in some vaccines – typically 25 μg per dose. [ 6 ] In 2022, the combination of neomycin with dexamethasone and polymyxin B was the 274th most commonly prescribed medication in the United States, with more than 800,000 prescriptions.
Natamycin has been used for decades in the food industry as a hurdle to fungal outgrowth in dairy products and other foods. Potential advantages for the usage of natamycin might include the replacement of traditional chemical preservatives, a neutral flavor impact, and less dependence on pH for efficacy, as is common with chemical preservatives.
Neomycin/polymyxin B/hydrocortisone, sold under the brand Otosporin among others, is a medication used to treat otitis externa (swimmer's ear) and certain eye disorders. [ 2 ] [ 3 ] It consists of the antibiotics neomycin and polymyxin B , and the steroid hydrocortisone . [ 3 ]
Neomycin/polymyxin B/bacitracin, also known as triple antibiotic ointment, is an antibiotic medication used to reduce the risk of infections following minor skin injuries. [ 1 ] [ 2 ] It contains the three antibiotics neomycin , polymyxin B , and bacitracin . [ 1 ]
Polymyxin B, sold under the brand name Poly-Rx among others, is an antibiotic used to treat meningitis, pneumonia, sepsis, and urinary tract infections. [1] While it is useful for many Gram negative infections, it is not useful for Gram positive infections. [1]
Though Polysporin is marketed in the US, it holds a much smaller market share than in Canada and acts as a substitute to Johnson & Johnson's Neosporin for those allergic to the antibiotic neomycin. However, allergy to bacitracin/polymyxin B has also been reported. [2] There is also an ophthalmological ointment, eye and ear drops.
Ophthalmic drug administration is the administration of a drug to the eyes, most typically as an eye drop formulation. Topical formulations are used to combat a multitude of diseased states of the eye. These states may include bacterial infections, eye injury, glaucoma, and dry eye. [1]
In most countries, neomycin and chloramphenicol eye drops are used, instead. [7] [8] However, newborns can develop neonatal conjunctivitis due to reactions with chemicals in these common eye drops. [9] A blocked tear duct may also be another noninfectious cause of neonatal conjunctivitis. [citation needed]