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People taking macrolide antibiotics, ketoconazole, or cyclosporine, or those who have liver or kidney disease, should not take colchicine, as these drugs and conditions may interfere with colchicine metabolism and raise its blood levels, potentially increasing its toxicity abruptly.
Another option is to use fluvastatin, a statin that is metabolized by CYP2C9, an enzyme that is not inhibited by clarithromycin. [14] Macrolides, including azithromycin, should not be taken with colchicine as it may lead to colchicine toxicity. Symptoms of colchicine toxicity include gastrointestinal upset, fever, myalgia, pancytopenia, and ...
Azithromycin, should not be taken with colchicine as it may lead to colchicine toxicity. Symptoms of colchicine toxicity include gastrointestinal upset, fever, myalgia, pancytopenia, and organ failure. [45] [46]
Colchicine to treat or prevent gout attacks. Antibiotics for bacterial infections. Steroids to decrease inflammation. Your healthcare provider may also use injections in the affected joint to ...
Use of clarithromycin with the following medications: cisapride, pimozide, astemizole, terfenadine, ergotamine, ticagrelor, ranolazine or dihydroergotamine is not recommended. [9] It should not be used with colchicine in people with kidney or liver impairment. [9] Concomitant use with cholesterol medications such as lovastatin or simvastatin. [9]
While colchicine is not used to treat cancer in humans, it is commonly used to treat acute attacks of gout. [26] Colchicine is an anti-inflammatory drug that has been in continuous use for more than 3000 years. Colchicine is an oral drug, known to be used for treating acute gout and preventing acute attacks of familial Mediterranean fever (FMF).
It should be considered in all patients with acute pericarditis, preferably in combination with a short-course of NSAIDs. [10] For patients with a first episode of acute idiopathic or viral pericarditis, they should be treated with an NSAID plus colchicine 1–2 mg on first day followed by 0.5 daily or twice daily for three months.
Colchicine alkaloids [144] Tyrosine or phenylalanine → dopamine → autumnaline → colchicine [145] Colchicine, colchamine [144] Muscarine [146] Glutamic acid → 3-ketoglutamic acid → muscarine (with pyruvic acid) [147] Muscarine, allomuscarine, epimuscarine, epiallomuscarine [146] Benzylamine [148] Phenylalanine with valine, leucine or ...
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