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Stem-cell transplantation was pioneered using bone marrow-derived stem cells by a team at the Fred Hutchinson Cancer Research Center from the 1950s through the 1970s led by E. Donnall Thomas, whose work was later recognized with a Nobel Prize in Physiology or Medicine. Thomas' work showed that bone-marrow cells infused intravenously could ...
Autologous stem-cell transplantation entry in the public domain NCI Dictionary of Cancer Terms; ScienceDaily Report Archived 2017-01-16 at the Wayback Machine University of Louisville. "Two years out, patients receiving stem cell therapy show sustained heart function improvement, study suggests." ScienceDaily, 6 Nov. 2012. Web. 6 Nov. 2012.
There are two types of stem cell (bone marrow) transplants: autologous stem cell transplant, where the person's own stem cells are collected, frozen, and stored before the chemotherapy regimen and transfused back into their body by IV after chemotherapy, and allogeneic stem cell transplant, where the stem cells come from a donor that matches ...
The IPSS-M model is useful for the risk stratification of patients with MDS to predict leukemia-free survival, overall survival, and risk of leukemic transformation. Patients with high, or very high-risk IPSS-M might benefit from allogeneic hematopoietic stem cell transplantation. [3]
Stem-cell therapy uses stem cells to treat or prevent a disease or condition. [1] As of 2024, the only FDA-approved therapy using stem cells is hematopoietic stem cell transplantation. [2] [3] This usually takes the form of a bone marrow or peripheral blood stem cell transplantation, but the cells can also be derived from umbilical cord blood.
A meta-analysis of 4 previous studies reported that 72 individuals receiving allogenic hematopoietic stem cell transplant (AHSCT) for RT (almost all cases were DLBCL-RT) achieved an overall response rate (percentage of patients showing a decrease in their disease) of 79%, complete response rate (percentage of patients showing an apparent ...
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