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Acute uric acid nephropathy is caused by deposition of uric acid crystals within the kidney interstitium and tubules, leading to partial or complete obstruction of collecting ducts, renal pelvis, or ureter. This obstruction is usually bilateral, and patients follow the clinical course of acute kidney failure.
Hyperuricosuria is a medical term referring to the presence of excessive amounts of uric acid in the urine. For men this is at a rate greater than 800 mg/day, and for women, 750 mg/day. [ 1 ] Notable direct causes of hyperuricosuria are dissolution of uric acid crystals in the kidneys or urinary bladder , and hyperuricemia .
Unless high blood levels of uric acid are determined in a clinical laboratory, hyperuricemia may not cause noticeable symptoms in most people. [5] Development of gout – which is a painful, short-term disorder – is the most common consequence of hyperuricemia, which causes deposition of uric acid crystals usually in joints of the extremities, but may also induce formation of kidney stones ...
Otherwise a noncontrast helical CT scan with 5 millimeters (0.2 in) sections is the diagnostic method to use to detect kidney stones and confirm the diagnosis of kidney stone disease. [ 16 ] [ 57 ] [ 61 ] [ 66 ] [ 7 ] Near all stones are detectable on CT scans with the exception of those composed of certain drug residues in the urine, [ 59 ...
High blood calcium, oxalate, or uric acid, can contribute to the risk of stone formation. In males, an enlarged prostate gland is a common cause of obstructive anuria. Acute anuria, where the decline in urine production occurs quickly, is usually a sign of obstruction or acute kidney failure .
The diagnosis is supported by a urine test strip which is positive for "blood" but the urine contains no red blood cells when examined with a microscope. [3] Blood tests show a creatine kinase activity greater than 1000 U/L, with severe disease being above 5000–15 000 U/L. [5] The mainstay of treatment is large quantities of intravenous ...
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