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In pharmacology, potency or biological potency [1] is a measure of a drug's biological activity expressed in terms of the dose required to produce a pharmacological effect of given intensity. [2]
It is commonly used as a measure of a drug's potency, although the use of EC 50 is preferred over that of 'potency', which has been criticised for its vagueness. [3] EC 50 is a measure of concentration, expressed in molar units (M), where 1 M is equivalent to 1 mol/L.
In pharmacology, an effective dose (ED) or effective concentration (EC) is the dose or concentration of a drug that produces a biological response. [1] [2] The term "effective dose" is used when measurements are taken in vivo, while "effective concentration" is used when the measurements are taken in vitro.
Potency may refer to: Potency (pharmacology), a measure of the activity of a drug in a biological system; Virility; Cell potency, a measure of the differentiation potential of stem cells; In homeopathic dilutions, potency is a measure of how dilute a substance is
IC 50 is commonly used as a measure of antagonist drug potency in pharmacological research. IC 50 is comparable to other measures of potency, such as EC 50 for excitatory drugs. EC 50 represents the dose or plasma concentration required for obtaining 50% of a maximum effect in vivo. [1]
The parameters of the dose response curve reflect measures of potency (such as EC50, IC50, ED50, etc.) and measures of efficacy (such as tissue, cell or population response). A commonly used dose–response curve is the EC 50 curve, the half maximal effective concentration, where the EC 50 point is defined as the inflection point of the curve.
MAC is used to compare the strengths, or potency, of anaesthetic vapours. [1] The concept of MAC was first introduced in 1965. [2] MAC actually is a median value, not a minimum as term implies. The original paper proposed MAC as the minimal alveolar concentration, [3] which was shortly thereafter revised to minimum alveolar concentration. [4]
To counter the reduced potency at high dilutions he formed the view that vigorous shaking by striking on an elastic surface – a process termed succussion – was necessary. [4] It has been said that Hahnemann came to this conclusion after deciding preparations subjected to agitation in transit, such as in saddle bags or in a carriage, were ...