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  2. Metabolic dysfunction–associated steatotic liver disease

    en.wikipedia.org/wiki/Metabolic_dysfunction...

    Second, insulin promotes the production of new FFAs in the liver via de novo lipogenesis; this production of liver fats continues to be stimulated by insulin, even when other tissues are insulin-resistant. [20] These FFAs are combined back into triglycerides in the liver, forming the major constituent of the accumulated fat in the liver. [20]

  3. Lipotoxicity - Wikipedia

    en.wikipedia.org/wiki/Lipotoxicity

    Lipotoxicity is a metabolic syndrome that results from the accumulation of lipid intermediates in non- adipose tissue, leading to cellular dysfunction and death. The tissues normally affected include the kidneys, liver, heart and skeletal muscle. Lipotoxicity is believed to have a role in heart failure, obesity, and diabetes, and is estimated ...

  4. Fatty Liver Disease: Risk Factors & Treatment Options - AOL

    www.aol.com/lifestyle/fatty-liver-disease-risk...

    In very severe cases, as the condition progresses, you might experience: Jaundice (when your skin or the whites of your eyes turn yellow due to liver damage) Swelling in your abdomen or legs. If ...

  5. Lipogenesis - Wikipedia

    en.wikipedia.org/wiki/Lipogenesis

    Lipogenesis. In biochemistry, lipogenesis is the conversion of fatty acids and glycerol into fats, or a metabolic process through which acetyl-CoA is converted to triglyceride for storage in fat. [1] Lipogenesis encompasses both fatty acid and triglyceride synthesis, with the latter being the process by which fatty acids are esterified to ...

  6. Niemann–Pick disease type C - Wikipedia

    en.wikipedia.org/wiki/Niemann–Pick_disease_type_C

    Niemann–Pick type C disease has a wide clinical spectrum. Affected individuals may have enlargement of the spleen (splenomegaly) and liver (hepatomegaly), or enlarged spleen or liver combined (hepatosplenomegaly), but this finding may be absent in later onset cases.

  7. Lipid metabolism - Wikipedia

    en.wikipedia.org/wiki/Lipid_metabolism

    Lipid metabolism. Lipid metabolism is the synthesis and degradation of lipids in cells, involving the breakdown and storage of fats for energy and the synthesis of structural and functional lipids, such as those involved in the construction of cell membranes. In animals, these fats are obtained from food and are synthesized by the liver. [1]