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3576 n/a Ensembl ENSG00000169429 n/a UniProt P10145 n/a RefSeq (mRNA) NM_000584 NM_001354840 n/a RefSeq (protein) NP_000575 NP_001341769 n/a Location (UCSC) Chr 4: 73.74 – 73.74 Mb n/a PubMed search n/a Wikidata View/Edit Human Interleukin 8 (IL-8 or chemokine (C-X-C motif) ligand 8, CXCL8) is a chemokine produced by macrophages and other cell types such as epithelial cells, airway smooth ...
The interleukin-8 receptors (IL-8R) are two 7-transmembrane proteins in the G-protein coupled-receptor family: [1] interleukin-8 receptor A (IL-8RA) and interleukin-8 receptor B (IL-8RB). These receptors are generally found on human neutrophils , a type of white blood cell of the myeloid lineage , with approximately 65,000 receptors per ...
Endothelial cells store IL-8 in their storage vesicles, the Weibel-Palade bodies. [26] [27] In humans, the interleukin-8 protein is encoded by the CXCL8 gene. [28] IL-8 is initially produced as a precursor peptide of 99 amino acids which then undergoes cleavage to create several active IL-8 isoforms. [29]
3577 227288 Ensembl ENSG00000163464 ENSMUSG00000048480 UniProt P25024 Q810W6 RefSeq (mRNA) NM_000634 NM_178241 RefSeq (protein) NP_000625 NP_839972 Location (UCSC) Chr 2: 218.16 – 218.17 Mb Chr 1: 74.23 – 74.23 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Interleukin 8 receptor, alpha is a chemokine receptor. This name and the corresponding gene symbol IL8RA have been replaced ...
Upon binding IL-15 to signaling complex, kinases of the Src family including Lck and Fyn are activated, and subsequently activates PI3K and MAPK signaling pathway. [18] The second mechanism of IL-15 action is cis-presentation, when IL-15 is presented by IL-15Rα to 15Rβγ c signaling complex on the same cell. This mechanism is mediated by the ...
2150 14063 Ensembl ENSG00000164251 ENSMUSG00000021678 UniProt P55085 P55086 RefSeq (mRNA) NM_005242 NM_007974 RefSeq (protein) NP_005233 NP_032000 Location (UCSC) Chr 5: 76.82 – 76.84 Mb Chr 13: 95.65 – 95.66 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Protease activated receptor 2 (PAR2) also known as coagulation factor II (thrombin) receptor-like 1 (F2RL1) or G-protein ...
The interleukin-28 receptor, once a ligand is bound will activate a signaling pathway that causes an increase in MHC class 1 production. [6] Once the type 3 interferons bind to their receptor, the resulting signaling cascade results in the production of IL-6, IL-8, and IL-10 by macrophages and monocytes. [9]
54106 81897 Ensembl ENSG00000239732 ENSMUSG00000045322 UniProt Q9NR96 Q9EQU3 RefSeq (mRNA) NM_138688 NM_017442 NM_031178 RefSeq (protein) NP_059138 NP_112455 Location (UCSC) Chr 3: 52.22 – 52.23 Mb Chr 9: 106.1 – 106.1 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Toll-like receptor 9 is a protein that in humans is encoded by the TLR9 gene. TLR9 has also been designated as ...