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Baclofen, sold under the brand name Lioresal among others, is a medication used to treat muscle spasticity, such as from a spinal cord injury or multiple sclerosis. [8] [9] It may also be used for hiccups and muscle spasms near the end of life, [9] and off-label to treat alcohol use disorder [10] [11] or opioid withdrawal symptoms. [12]
While gabapentin can be helpful in a number of circumstances, some of the common side effects associated with taking the drug as directed include drowsiness, dizziness, headache, dry mouth, weight ...
Similarly, gabapentin enacarbil is transported not by the LAT1 but by the monocarboxylate transporter 1 (MCT1) and the sodium-dependent multivitamin transporter (SMVT), and no saturation of bioavailability has been observed with the drug up to a dose of 2,800 mg. [25] Similarly to gabapentin and pregabalin, baclofen, a close analogue of ...
Gabapentin is recommended for use in focal seizures and neuropathic pain. [7] [10] Gabapentin is prescribed off-label in the US and the UK, [22] [23] for example, for the treatment of non-neuropathic pain, [22] anxiety disorders, sleep problems and bipolar disorder. [24] In recent years, gabapentin has seen increased use, particularly in the ...
Gabapentin could cause ED, desire changes and dysfunction. There’s evidence that gabapentin may affect a man’s ability to reach climax (either by causing PE or delayed climax), especially if ...
[59] [60] Like most anticonvulsants, pregabalin and gabapentin have an increased risk of suicidal thoughts and behaviors. [61] [62] Gabapentinoids, like all calcium channel blockers, are known to cause angioedema. [63] Taking them with an ACE inhibitor can increase the toxic effects of gabapentinoids. [64]
Constipation is the most common chronic gastrointestinal disorder in adults. Depending on the definition employed, it occurs in 2% to 20% of the population. [18] [58] It is more common in women, the elderly and children. [58] Specifically constipation with no known cause affects females more often affected than males. [59]
Obstructed defecation syndrome (abbreviated as ODS, with many synonymous terms) is a major cause of functional constipation (primary constipation), [19] of which it is considered a subtype. [20] It is characterized by difficult and/or incomplete emptying of the rectum with or without an actual reduction in the number of bowel movements per week ...