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Hyperpolarized gas MRI, also known as hyperpolarized helium-3 MRI or HPHe-3 MRI, is a medical imaging technique that uses hyperpolarized gases to improve the sensitivity and spatial resolution of magnetic resonance imaging (MRI).
Hyperpolarization machines are currently being used to develop hyperpolarized xenon gas that is used as a visualization agent for the lungs. Xenon-129 is a safe inert noble gas that can be used to quantify lung function. With a single 10-second breath hold, hyperpolarized Xenon-129 is used with MRI to enable 3-dimensional lung imaging. [35]
The hyperpolarization creates a large signal intensity, and the wide range of chemical shifts allows for identifying when the 129 Xe associates with molecules like hemoglobin. 129 Xe is preferred over 131 Xe for MRI because 129 Xe has spin 1/2 (compared to 3/2 for 131 Xe), a longer T1 , and 3.4 times larger gyromagnetic ratio (11.78 MHz/T).
Dynamic nuclear polarization (DNP) is one of several hyperpolarization methods developed to enhance the sensitivity of nuclear magnetic resonance (NMR) spectroscopy.While an essential analytical tool with applications in several fields, NMR’s low sensitivity poses major limitations to analyzing samples with low concentrations and limited masses and volumes. [1]
Hyperpolarization is a change in membrane potential. Neuroscientists measure it using a technique known as patch clamping that allows them to record ion currents passing through individual channels. This is done using a glass micropipette, also called a patch pipette, with a 1 micrometer diameter.
[1] The company was founded when Ugur Cooling started ice cream machine production in Nazilli in 1954. Today, the company produces a range of equipment including deep freezers to bottled water coolers , motorcycles, scooters and cosmetics , with the company operating Europe's second-biggest refrigeration plant in Nazilli. [ 2 ]
Although the system is a variant of STAMP, it is mainly designed to be fitted with the 12.7 mm GAU-19/A three-barrel rotary heavy machine gun. It can also be fitted with either a 12.7 mm M2HB heavy machine gun, 7.62 mm FN Minimi light machine gun or a 40 mm MK 19 automatic grenade launcher. [3]
In the following years, Hidromek was engaged in the business of producing and assembling loader and digger attachments on the agricultural tractors and converting them into a construction machine. In 1989, Hidromek produced its first original machine, the first backhoe loader. In 1999, Hidromek made its first international sale to Tunisia.