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Risk factors for endometrial cancer include obesity, metabolic syndrome, type 2 diabetes, taking pills that contain estrogen without progesterone, a history of tamoxifen use, late menopause, and a family history of the condition. [7] [1] Risk factors for uterine sarcoma include prior radiation therapy to the pelvis. [2]
Uterine clear-cell carcinoma (CC) is a rare form of endometrial cancer with distinct morphological features on pathology; it is aggressive and has high recurrence rate. Like uterine papillary serous carcinoma CC does not develop from endometrial hyperplasia and is not hormone sensitive, rather it arises from an atrophic endometrium.
Endometrial intraepithelial neoplasia (EIN) is a premalignant lesion of the uterine lining that predisposes to endometrioid endometrial adenocarcinoma. It is composed of a collection of abnormal endometrial cells, arising from the glands that line the uterus , which have a tendency over time to progress to the most common form of uterine cancer ...
The Galleri test, which is available by prescription from a health care provider or through independent telehealth providers, is recommended for adults with a higher risk for cancer, including ...
Postmenopausal Black women who reported using hair relaxers more than twice a year or for more than five years had a greater than 50% increased risk of uterine cancer.
In trans men who take testosterone and have not had a hysterectomy, the conversion of testosterone into estrogen via androstenedione may lead to a higher risk of endometrial cancer. [24] Higher circulating testosterone levels in women have also been identified as an independent endometrial cancer risk factor. [25] [unreliable medical source]
Uterine serous carcinoma is a malignant form of serous tumor that originates in the uterus. It is an uncommon form of endometrial cancer that typically arises in postmenopausal women. It is typically diagnosed on endometrial biopsy , prompted by post-menopausal bleeding .
Each assay may give different results of the clinical value of the p53 mutations as a prognostic factor. [5] Interlaboratory proficiency testing for tumor marker tests, and for clinical tests more generally, is routine in Europe and an emerging field [6] in the United States. New York state is prominent in advocating such research. [7]