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Vitamin D toxicity, also called hypervitaminosis D, is a rare but potentially serious condition that occurs when you have excessive amounts of vitamin D in your body. Vitamin D toxicity is usually caused by large doses of vitamin D supplements — not by diet or sun exposure.
Too much calcium in the blood can cause weakness, lead to kidney stones, and interfere with the heart and brain, and even be life threatening. The Mayo researchers also found that women over age 65 were at the highest risk of having vitamin D levels above 50 ng/mL.
Its anti-inflammatory, antioxidant and neuroprotective properties support immune health, muscle function and brain cell activity. Vitamin D isn't naturally found in many foods, but you can get it from fortified milk, fortified cereal, and fatty fish such as salmon, mackerel and sardines.
Vitamin D intoxication associated with hypercalcemia, hyperphosphatemia, and suppressed parathyroid hormone level is typically seen in patients who are receiving massive doses of vitamin D in the range of 50,000 to 1 million IU/d for several months to years.
Vitamin D toxicity (hypervitaminosis D) happens when you have too much vitamin D in your body. It’s a rare complication that most often happens from taking higher-than-prescribed amounts of prescription vitamin D or too much of a self-prescribed over-the-counter (OTC) supplement.
Toxicity of vitamin D leads to hypercalcemia and an imbalance in the regulation of bone metabolism; the resultant hypercalcemia leads to clinical manifestations and symptoms of toxicity. This activity reviews the etiology, evaluation, and treatment of vitamin D toxicity.
Vitamin D deficiency — when the level of vitamin D in your body is too low — can cause your bones to become thin, brittle or misshapen. Vitamin D also appears to play a role in insulin production and immune function — and how this relates to chronic disease prevention and cancer — but this is still being investigated.
On completion of this article, you should be able to (1) recognize patients at risk for vitamin D deficiency, (2) optimally use and interpret serum vitamin D testing, and (3) determine the optimal vitamin D therapy required to treat or prevent vitamin D deficiency in adults.
If left untreated over time, vitamin D deficiency can lead to serious bone disorders. For example, severe and long-term vitamin D deficiency may result in rickets or osteomalacia.
Mayo Clinic recommends that adults get at least the RDA of 600 IU. However, 1,000 to 2,000 IU per day of vitamin D from a supplement is generally safe, should help people achieve an adequate blood level of vitamin D, and may have additional health benefits.