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Vitamin B12 deficiency, also known as cobalamin deficiency, is the medical condition in which the blood and tissue have a lower than normal level of vitamin B 12. [ 5 ] Symptoms can vary from none to severe. [ 1 ] Mild deficiency may have few or absent symptoms. [ 1 ]
[6] [14] [25] Vitamin B 12 deficiency can also cause symptoms of mania and psychosis. [26] [27] Among other problems, weakened immunity, reduced fertility and interruption of blood circulation in women may occur. [28] The main type of vitamin B12 deficiency anemia is pernicious anemia, [29] characterized by a triad of symptoms:
Frequency. 1 per 1000 people [8] Pernicious anemia is a disease where not enough red blood cells are produced due to a deficiency of vitamin B 12. [5] Those affected often have a gradual onset. [5] The most common initial symptoms are feeling tired and weak. [4]
A vitamin B12 deficiency can be caused by a gastrointestinal disorder or a lack of B12 in your diet. Signs of a B12 deficiency include weakness, fatigue, and tingling or numbness in the hands and ...
B12 is crucial for many important functions, and, with a few exceptions, the only way to get it is through animal-based foods or B12 supplements. “Vitamin B12 is an essential water-soluble ...
Megaloblastic anemia, the most common cause of macrocytic anemia, is due to a deficiency of either vitamin B 12, folic acid, or both. [78] Deficiency in folate or vitamin B 12 can be due either to inadequate intake or insufficient absorption. Folate deficiency normally does not produce neurological symptoms, while B 12 deficiency does.