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Wolff's law, developed by the German anatomist and surgeon Julius Wolff (1836–1902) in the 19th century, states that bone in a healthy animal will adapt to the loads under which it is placed. [1] If loading on a particular bone increases, the bone will remodel itself over time to become stronger to resist that sort of loading.
The basis of osteogenic loading stems from Wolff's law, [5] which shows that the force or loading on bone through its axis, can stimulate the bone's natural function of increasing in density. Further study has shown that greater loads on bone can stimulate a greater effect of the body to respond and increase the density of bone, and can show ...
Bone tissue is removed by osteoclasts, and then new bone tissue is formed by osteoblasts. Both processes utilize cytokine (TGF-β, IGF) signalling.In osteology, bone remodeling or bone metabolism is a lifelong process where mature bone tissue is removed from the skeleton (a process called bone resorption) and new bone tissue is formed (a process called ossification or new bone formation).
Davis's law is used in anatomy and physiology to describe how soft tissue models along imposed demands. It is similar to Wolff's law , which applies to osseous tissue . It is a physiological principle stating that soft tissue heal according to the manner in which they are mechanically stressed.
This led to the rebirth of bone biomechanics when the railroad engineer Karl Culmann and the anatomist Hermann von Meyer compared the stress patterns in a human femur with those in a similarly shaped crane. Inspired by this finding Julius Wolff proposed the famous Wolff's law of bone remodeling. [23]
The Mechanostat is often defined as a practical description of Wolff's law described by Julius Wolff (1836–1902), but this is not completely accurate. Wolff wrote his treatises on bone after images of bone sections were described by Culmann and von Meyer, who suggested that the arrangement of the struts (trabeculae) at the ends of the bones ...
The EU says its AI Act is the world's most comprehensive law governing the use of AI, but it has been criticised by some companies for stifling innovation. "In Europe, we went too far and too fast ...
the histological proof of micro-damages in human bone biopsies; the basic model of the adaptation of the Growth plate to mechanical stress; the Utah-Paradigm of Bone physiology (Mechanostat-Theorem), an enhancement of Wolff's law stating that Bone adapts to mechanical stress and that hence there is a close link between muscle and bone