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Deoxyribonuclease II (DNase II) is also known as acid deoxyribonuclease because it has optimal activity in the low pH environment of lysosomes where it is typically found in higher eukaryotes. Some forms of recombinant DNase II display a high level of activity in low pH in the absence of divalent metal ions, similar to eukaryotic DNase II. [7]
Livedo reticularis is a common skin finding consisting of a mottled reticulated vascular pattern that appears as a lace-like purplish discoloration of the skin. [1] The discoloration is caused by reduction in blood flow through the arterioles that supply the cutaneous capillaries, resulting in deoxygenated blood showing as blue discoloration ().
The skin of amphibians is a major site of respiration in all species for which measurements are available. [2] Cutaneous respiration is the sole respiratory mode of lungless salamanders (family Plethodontidae) which lack lungs entirely yet constitute the largest family of salamanders. Cutaneous respiration in frogs and other amphibians may be ...
In most cases skin lesions do not cause symptoms, however itching, burning, or pain may occur. [5] Frequently reported symptoms include mild fever, muscle pain, joint pain, or an overall feeling of discomfort. [6] [8] Additional symptoms depend on the cause of the vasculitis and if other organ systems are involved.
Post-streptococcus glomerulonephritis is more often associated with group A strep skin infection than it is with strep pharyngitis, so in a patient with suspected post-strep glomerulonephritis with a negative ASO titer, one can then obtain anti-DNase-B titers which are more sensitive for group A strep and for its various strains.
When RecBCD reaches the end of the DNA, all three subunits disassemble and the enzyme remains inactive for an hour or more; [13] a RecBCD molecule that acted at Chi does not attack another DNA molecule. (2) If Mg 2+ ions are in excess, RecBCD cleaves both DNA strands endonucleolytically, although the 5' tail is cleaved less often (Figure 3). [14]
Deoxyribonuclease gamma (also termed DNase γ, deoxyribonuclease 1L3, DNASE1L3, of deoxyribonuclease I like 3) is an enzyme that in humans is encoded by the DNASE1L3 ...
Deoxyribonuclease I (usually called DNase I), is an endonuclease of the DNase family coded by the human gene DNASE1. [5] DNase I is a nuclease that cleaves DNA preferentially at phosphodiester linkages adjacent to a pyrimidine nucleotide , yielding 5'-phosphate-terminated polynucleotides with a free hydroxyl group on position 3', on average ...