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Its effects, depending on dosage, include an increase in sodium excretion by the kidneys, an increase in urine output, an increase in heart rate, and an increase in blood pressure. [13] At low doses it acts through the sympathetic nervous system to increase heart muscle contraction force and heart rate, thereby increasing cardiac output and ...
Dopamine dosage; though it is not a tdcs parameter it should be considered while its application in PD. There is clear non-linear, dosage dependent effects f dopamine in facilitatory and inhibitory plasticity and specific dopamine dosage is optimally suited to improve plasticity. [33]
The second important effect of dopamine is ... Its effects, depending on dosage, ... have shown that the amount of dopamine release is dependent on the strength ...
The effect that apomorphine has on the dopamine receptors can also be linked to the similarities between its structure and dopamine. [38] It is a chiral molecule and thus can be acquired in both the R and S form, the R form is the one that is used in therapy.
Levetiracetam, an antiepileptic drug which has been demonstrated to reduce the severity of levodopa-induced dyskinesias, has been shown to dose-dependently decrease the induction of dorsal striatal ΔFosB expression in rats when co-administered with levodopa. Although the signal transduction mechanism involved in this effect is unknown. [12]
A dopamine reuptake inhibitor (DRI) is a class of drug which acts as a reuptake inhibitor of the monoamine neurotransmitter dopamine by blocking the action of the dopamine transporter (DAT). Reuptake inhibition is achieved when extracellular dopamine not absorbed by the postsynaptic neuron is blocked from re-entering the presynaptic neuron.
Recent research has found that high-dose prescription amphetamines, often used to treat ADHD, are linked to a seriously heightened risk of psychosis. ... such as dopamine, which are also related ...
Amfonelic acid has been shown to be neuroprotective against methamphetamine damage to dopamine neurons. [10] It also increases the effects of the antipsychotic drugs haloperidol, trifluoperazine and spiperone. [11] Rats are shown to self-administer amfonelic acid in a dose-dependent manner. [12]