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Histamine is involved in the inflammatory response and has a central role as a mediator of itching. [6] As part of an immune response to foreign pathogens, histamine is produced by basophils and by mast cells found in nearby connective tissues.
A mast cell (also known as a mastocyte or a labrocyte [1]) is a resident cell of connective tissue that contains many granules rich in histamine and heparin.Specifically, it is a type of granulocyte derived from the myeloid stem cell that is a part of the immune and neuroimmune systems.
Enterochromaffin-like cells (ECL cells) are a population of cells that are found in the gastric glands of the stomach luminal epithelium and secrete histamine. In response to gastrin released by neighbouring G-cells, secreted histamine from ECL cells acts on parietal cells to stimulate the release of gastric acid.
Histamine dilates blood vessels, ... IFN is secreted through secretory vesicles, where it can activate receptors on both the cell it was released from ...
In mammals, histamine is an important biogenic amine with regulatory roles in neurotransmission, gastric acid secretion and immune response. [1] [2] Histidine decarboxylase is the sole member of the histamine synthesis pathway, producing histamine in a one-step reaction. Histamine cannot be generated by any other known enzyme.
ACh is secreted by parasympathetic nerve fibers of both the short and long reflex ,.ml; pathways. Histamine is a paracrine secretion from the enteroendocrine cells in the gastric glands. Gastrin is a hormone produced by enteroendocrine G cells in the pyloric glands.
The release of histamine is stimulated by the secretion of gastrin from the G cells. [1] Histamine promotes the production and release of HCL from the parietal cells to the blood and protons to the stomach lumen. When the stomach pH decreases (becomes more acidic), the ECLs stop releasing histamine. G cells – They secrete gastrin hormone ...
Enterochromaffin-like cells are enteroendocrine and neuroendocrine cells also known for their similarity to chromaffin cells secreting histamine, which stimulates G cells to secrete gastrin. Other hormones produced include cholecystokinin, somatostatin, vasoactive intestinal peptide, substance P, alpha and gamma-endorphin. [10] [24]