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Cutaneous squamous-cell carcinoma (cSCC), also known as squamous-cell carcinoma of the skin or squamous-cell skin cancer, is one of the three principal types of skin cancer, alongside basal-cell carcinoma and melanoma. [10] cSCC typically presents as a hard lump with a scaly surface, though it may also present as an ulcer. [1]
Conditions of or affecting the human integumentary system associated with increased risk of nonmelanoma skin cancer Condition Squamous-cell carcinoma Basal-cell carcinoma; Xeroderma pigmentosum + + Oculocutaneous albinism + + Epidermodysplasia verruciformis + Recessive dystrophic epidermolysis bullosa + Ferguson–Smith syndrome + Muir–Torre ...
Skin cancers result in 80,000 deaths a year as of 2010, 49,000 of which are due to melanoma and 31,000 of which are due to non-melanoma skin cancers. [74] This is up from 51,000 in 1990. [74] More than 3.5 million cases of skin cancer are diagnosed annually in the United States, which makes it the most common form of cancer in that country.
These cells form on the surface of the skin, on the lining of hollow organs in the body, and on the lining of the respiratory and digestive tracts. [1] The squamous-cell carcinomas of different body sites can show differences in their presented symptoms, natural history, prognosis, and response to treatment.
Skin cancer is the uncontrolled proliferation of abnormal skin cells, usually developing on skin exposed to ultraviolet radiation. Squamous cell carcinoma , basal cell carcinoma , and melanoma are the three main types of skin cancer, [ 5 ] with the former two being non-melanoma skin cancer.
In Canada, the most common skin cancer is basal-cell carcinoma (as much as one third of all cancer diagnoses), affecting 1 in 7 individuals over a lifetime. [66] This tumor accounts for approximately 70% of non-melanoma skin cancers. In 80 percent of all cases, basal-cell carcinoma affects head or neck skin. [65]
Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer occurring in about three people per million members of the population. [1] It is also known as cutaneous APUDoma, primary neuroendocrine carcinoma of the skin, primary small cell carcinoma of the skin, and trabecular carcinoma of the skin. [2]
Some commentators argue that skin cancer surgery, including Mohs surgery, is overutilised as rates of skin cancer surgery are increasing worldwide. It is unclear if this relates to higher rates of skin cancer, increased vigilance in diagnosis, and increased availability of the procedure, or patient and doctor preferences.