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The major causes of hepatic jaundice are significant damage to hepatocytes due to infectious, drug/medication-induced, autoimmune etiology, or less commonly, due to inheritable genetic diseases. [27] The following is a partial list of hepatic causes to jaundice: [28] Acute hepatitis; Chronic hepatitis; Hepatotoxicity; Cirrhosis; Drug-induced ...
Chronic liver diseases like chronic hepatitis, chronic alcohol abuse or chronic toxic liver disease may cause liver failure and hepatorenal syndrome; fibrosis and cirrhosis of liver; Cirrhosis may also occur in primary biliary cirrhosis. Rarely, cirrhosis is congenital.
Gilbert's syndrome, a genetic disorder of bilirubin metabolism found in a small percent of the population, can cause mild jaundice. [ 14 ] Cirrhosis is the formation of fibrous tissue ( fibrosis ) in the place of liver cells that have died due to a variety of causes, including viral hepatitis, alcohol overconsumption, and other forms of liver ...
Classification and diagnosis of the underlying disease of hyperbilirubinemia are crucial for prescription of treatment. [6] Physical examination reviews clinical symptoms like degree of jaundice, vital signs and sensations of pain, further followed by urine tests, blood analysis and imaging.
Treatment of the condition is specific to the cause of hemolysis, but intense phototherapy and exchange transfusion can be used to help the patient excrete accumulated bilirubin. [11] Complications related to hemolytic jaundice include hyperbilirubinemia and chronic bilirubin encephalopathy, which may be deadly without proper treatment. [12] [13]
Pathological jaundice in newborns should be suspected when the serum bilirubin level rises by more than 5 mg/dL per day, serum bilirubin more than the physiological range, clinical jaundice more than 2 weeks, and conjugated bilirubin (dark urine staining clothes). Haemolytic jaundice is the commonest
Transformation to hepatocellular carcinoma is more common in men. [2] Currently, if the hepatic adenoma is >5 cm, increasing in size, symptomatic lesions, has molecular markers associated with HCC transformation, rising level of liver tumor markers such as alpha fetoprotein , the patient is a male, or has a glycogen storage disorder , the ...
Acute liver failure (with hepatocellular necrosis and sinusoidal bleeding) from Marburg virus, a rare cause: Specialty: Gastroenterology, hepatology, intensive care medicine Symptoms: Jaundice, excessive bleeding, altered state of consciousness, hyperdynamic circulation, hepatocellular necrosis, low blood pressure: Complications
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