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Genetic equilibrium describes a theoretical state that is the basis for determining whether and in what ways populations may deviate from it. Hardy–Weinberg equilibrium is one theoretical framework for studying genetic equilibrium. It is commonly studied using models that take as their assumptions those of Hardy-Weinberg, meaning:
In the absence of selection, mutation, genetic drift, or other forces, allele frequencies p and q are constant between generations, so equilibrium is reached. The principle is named after G. H. Hardy and Wilhelm Weinberg, who first demonstrated it mathematically.
Mutation–selection balance is an equilibrium in the number of deleterious alleles in a population that occurs when the rate at which deleterious alleles are created by mutation equals the rate at which deleterious alleles are eliminated by selection.
(See note below about genetic nomenclature) If the A and B alleles are independent in a population, then, by definition, p AB is simply the product p A p B. The difference between these two is given the designation D, the 'coefficient of linkage disequilbrium': D = p AB - p A p B. Departure of D from zero indicates LD.
A Punnett square visualizing the genotype frequencies of a Hardy–Weinberg equilibrium as areas of a square. p (A) and q (a) are the allele frequencies . Genetic variation in populations can be analyzed and quantified by the frequency of alleles .
Population genetics describes the genetic composition of a population, including allele frequencies, and how allele frequencies are expected to change over time. The Hardy–Weinberg law describes the expected equilibrium genotype frequencies in a diploid population after random mating. Random mating alone does not change allele frequencies ...
However, the punctuational equilibrium model may still be inferred from both the observation of stasis and examples of rapid and episodic speciation events documented in the fossil record. [70] Dawkins also emphasizes that punctuated equilibrium has been "oversold by some journalists", [71] but partly due to Eldredge and Gould's "later writings ...
In population genetics, F-statistics (also known as fixation indices) describe the statistically expected level of heterozygosity in a population; more specifically the expected degree of (usually) a reduction in heterozygosity when compared to Hardy–Weinberg expectation.