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Mouse Genome Informatics (MGI) is a free, online database and bioinformatics resource hosted by The Jackson Laboratory, with funding by the National Human Genome Research Institute (NHGRI), the National Cancer Institute (NCI), and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). [1]
Many laboratory animals, including mice and rats, are chronically stressed which can also negatively affect research outcomes and the ability to accurately extrapolate findings to humans. [32] [33] Researchers have also noted that many studies involving mice, rats and other rodents are poorly designed, leading to questionable findings.
Self-archiving by authors is permitted under green OA. Independently from publication by a publisher, the author also posts the work to a website controlled by the author, the research institution that funded or hosted the work, or to an independent central open repository, where people can download the work without paying.
The genetically modified mouse in which a gene affecting hair growth has been knocked out (left) shown next to a normal lab mouse. A genetically modified mouse, genetically engineered mouse model (GEMM) [1] or transgenic mouse is a mouse (Mus musculus) that has had its genome altered through the use of genetic engineering techniques.
This is an accepted version of this page This is the accepted version, checked on 5 February 2025. There are template/file changes awaiting review. Use of animals in experiments "Animal research" redirects here. For other uses, see Animal studies (disambiguation). For the journal, see Animal Research (journal). See also: Vivisection A Wistar laboratory rat Description Around 50–100 million ...
The albino laboratory mouse is an iconic model organism for scientific research in a variety of fields An SCID Intermediate coat colour Kept as a pet. The laboratory mouse or lab mouse is a small mammal of the order Rodentia which is bred and used for scientific research or feeders for certain pets.
Humanized mice are commonly used as small animal models in biological and medical research for human therapeutics. [ 2 ] A humanized mouse or a humanized mouse model is one that has been xenotransplanted with human cells and/or engineered to express human gene products, so as to be utilized for gaining relevant insights in the in vivo context ...
This is, in part, because different stakeholders (e.g. animal experimenters, institutional figures, policy makers, activists and the public) may interpret the Three Rs differently. [ 19 ] [ 20 ] The 3Rs principles do not address some issues, such as the ethics of using animals in research and focus instead on improving the humane use of animals ...