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CBD is believed to regulate the metabolism of THC by inactivating cytochrome P450 enzymes that metabolize drugs; one such mechanism is via generation of carbon monoxide (a pharmacologically active neurotransmitter) by upon metabolism of CBD. [14] THC is converted rapidly to 11-hydroxy-THC, which is also pharmacologically active, so the euphoria ...
What does weed do to your testosterone? Maybe not a lot, according to research on marijuana/THC use and testosterone levels. What marijuana really does to your testosterone
Over time, the marijuana gateway hypothesis has been studied more and more. In one published study, the use of marijuana was shown not a reliable gateway cause of illicit drug use. [67] However, social factors and environment influence drug use and abuse, making the gateway effects of cannabis different for those in differing social circumstances.
[64] 11-OH-THC is the first metabolic product in this pathway. Both Delta-9-THC and 11-OH-THC are psychoactive. The metabolism of THC into 11-OH-THC plays a part in the heightened psychoactive effects of edible cannabis. [65] Next, 11-OH-THC is metabolized in the liver into 11-COOH-THC, which is the second metabolic product of THC.
I had a blast on a recent four-mile run, and it wasn’t because of the location or my playlist. It was because I was actually high.
Like Δ 9-THC, 11-hydroxy-THC is a partial agonist at the cannabinoid receptor CB 1, but with significantly higher binding affinity (K i = 0.37 nM compared to Δ 9-THC K i = 35 nM). [7] With respect to cAMP inhibition at CB 1 it displays a similar efficacy to that of Δ 9 -THC (EC 50 = 11 nM vs. EC 50 = 5.2 nM, respectively), but a lower ...
Although it might sound promising as an easy hack to boost your metabolism, metabolic confusion isn’t a slam dunk for weight loss, nutritionists say. “The body doesn't operate in a way that ...
This metabolism starkly contrasts that of Δ 9-THC in terms of potency, given that 11-OH-THC has been reported to have 10× the potency of Δ 9-THC. Due to high lipophilicity and first-pass metabolism, there is low bioavailability of CBN and other cannabinoids following oral administration. CBN metabolism is mediated in part by CYP450 isoforms ...