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The statins differ with respect to their ring structure and substituents. These differences in structure affect the pharmacological properties of the statins, such as: [6] Affinity for the active site of the HMGR; Rates of entry into hepatic and non-hepatic tissues; Availability in the systemic circulation for uptake into non-hepatic tissues
Statins with shorter half-lives are more effective when taken in the evening, so their peak effect occurs when the body's natural cholesterol production is at its highest. A recent meta-analysis suggested that statins with longer half-lives, including atorvastatin, may also be more effective at lowering LDL cholesterol if taken in the evening. [40]
Statins are usually used to lower blood cholesterol levels and reduce risk for illnesses related to atherosclerosis, with a varying degree of effect depending on underlying risk factors and history of cardiovascular disease. [16]
According to the study authors, their findings could help researchers better understand how to treat problems that affect memory. They also offer fresh insights into how human memory, as a whole ...
memory loss or forgetfulness; confusion; The following rare side effects are more serious. Like all statins, rosuvastatin can possibly cause myopathy, rhabdomyolysis: [14] [4] muscle pain, tenderness, or weakness; lack of energy; fever; chest pain; jaundice: yellowing of the skin or eyes; dark colored, or foamy urine; pain in the upper right ...
A new way of determining heart disease risk may result in millions fewer people getting prescriptions for statins, according to new research. Heart doctors warned, however, that more information ...
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