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The erythrocyte sedimentation rate (ESR or sed rate) is the rate at which red blood cells in anticoagulated whole blood descend in a standardized tube over a period of one hour. It is a common hematology test, and is a non-specific measure of inflammation .
A laboratory ultracentrifuge. In chemistry, a Svedberg unit or svedberg (symbol S, sometimes Sv [a]) is a non-SI metric unit for sedimentation coefficients.The Svedberg unit offers a measure of a particle's size indirectly based on its sedimentation rate under acceleration (i.e. how fast a particle of given size and shape settles out of suspension). [1]
Sedimentation rate may refer to: Sedimentation rate of particles in a liquid, described by Stokes' law; Erythrocyte sedimentation rate, a medical test for inflammation;
The flat surface of the discoid RBCs gives them a large surface area to make contact with and stick to each other; thus forming a rouleau. They occur when the plasma protein concentration is high, and, because of them, the ESR (erythrocyte sedimentation rate) is also increased. This is a nonspecific indicator of the presence of disease.
Erythrocyte aggregation is the main determinant of blood viscosity at low shear rate. Rouleaux formation also determines Erythrocyte sedimentation rate which is a non-specific indicator of the presence of disease. [6] Influence of erythrocyte aggregation on in vivo blood flow is still a controversial issue. [7]
Recent non-consolidated radiolarian oozes have sedimentation rates of 1 to 5 meters/million years. [7] In radiolarian oozes deposited in the equatorial Eastern Atlantic 11.5 meters/million years have been measured. In upwelling areas like off the Peruvian coast extremely high values of 100 meters/million years were reported [citation needed].
Sedimentation depends on mass, shape, and partial specific volume of a macromolecule, as well as solvent density, rotor size and rate of rotation. The sedimentation velocity can be monitored during the experiment to calculate molecular weight. Values of sedimentation coefficient (S) can be calculated. Large values of S (faster sedimentation ...
The sedimentation coefficient is typically dependent on the concentration of the solute (i.e. a macromolecular solute such as a protein). Despite 80+ years of study, there is not yet a consensus on the way to perfectly model this relationship while also taking into account all possible non-ideal terms to account for the diverse possible sizes, shapes, and densities of molecular solutes. [2]