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Some of its side effects, including breast pain/tenderness and gynecomastia, are far less likely to occur when the drug is combined with a GnRH analogue, [205] while certain other side effects, including hot flashes, depression, fatigue, and sexual dysfunction, [206] occur much more frequently in combination with a GnRH analogue.
It has been said that the only advantage of CPA over castration is its relatively low incidence of hot flashes, a benefit that is mediated by its progestogenic activity. [97] Due to increased estrogen levels, bicalutamide and other NSAAs are similarly associated with low rates of hot flashes (9.2% for bicalutamide vs. 5.4% for placebo in the ...
Bellergal was widely used during the 1970s and 1980s. Its limited efficacy on decreasing hot flashes frequency and severity were demonstrated by several randomized controlled trials. After 2 weeks of therapy, bellergal significantly reduced hot flashes, according to a randomized controlled experiment from the 1980s.
Severe hot flashes Sudden intense flushing and sweating in the upper body—especially the face, neck, and chest—is a normal and frequent experience for women approaching and in menopause.
Muscle cramps, dizziness, fatigue, nausea, and vomiting might happen, as well. When the weather is warm, you might get dehydrated or end up with heat exhaustion, which triggers chills.
A medical event will also likely accompany other symptoms, like hot flashes, nausea, sudden sweating, shortness of breath, tremors, or heart palpitations, she adds. Impending doom may be a symptom ...
The most common side effects (more than 10% of patients) are hot flashes and sweating, which are typical of estrogen deficiency as caused by exemestane, and also insomnia, headache, and joint pain. Nausea and fatigue are mainly observed in patients with advanced breast cancer. [7] [8]
Hot flashes are sudden feelings of heat that can affect the face, neck and chest. They can also cause your skin to flush and sweat. Hot flashes can come in waves throughout the day and night and ...