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Hemoglobin-AGE levels are elevated in diabetic individuals [24] and other AGE proteins have been shown in experimental models to accumulate with time, increasing from 5-50 fold over periods of 5–20 weeks in the retina, lens and renal cortex of diabetic rats. The inhibition of AGE formation reduced the extent of nephropathy in diabetic rats. [25]
The researchers fed both male and female mice food containing 0.15% aspartame daily — the equivalent of a person drinking three cans (or about 1 litre) of diet soda a day — for 12 weeks.
Health groups ‘advising a bit of moderation’ on aspartame consumption
Aspartame is about 180 to 200 times sweeter than sucrose (table sugar). Due to this property, even though aspartame produces roughly the same energy per gram when metabolized as sucrose does, 4 kcal (17 kJ), the quantity of aspartame needed to produce the same sweetness is so small that its caloric contribution is negligible. [10]
The fluctuation of blood sugar (red) and the sugar-lowering hormone insulin (blue) in humans during the course of a day with three meals. One of the effects of a sugar-rich vs a starch-rich meal is highlighted. [1] The blood sugar level, blood sugar concentration, blood glucose level, or glycemia is the measure of glucose concentrated in the blood.
Aspartame is a non-nutritive sweetener, meaning it contains an extremely tiny or zero amount of carbohydrates and doesn’t provide the body with energy — or calories — as sugar does.