Ad
related to: endocytosis pathway- Supelco Product Catalog
View Supelco's Interactive Catalog
w/ Analytical Resources and Tools
- Lab Products & Equipment
Shop our huge portfolio of labware
equipment from leading brands.
- Sign In
Sigma® Life Science
View contract pricing, get quotes
- Sigma® Life Science
Find cell culture, antibodies and
thousands of biological products
- Supelco Product Catalog
Search results
Results From The WOW.Com Content Network
Dynamin-dependent clathrin-independent pathways include FEME, UFE, ADBE, EGFR-NCE and IL2Rβ uptake. [10] Dynamin-independent clathrin-independent pathways include the CLIC/GEEC pathway (regulated by Graf1), [11] as well as MEND and macropinocytosis. [10] Clathrin-mediated endocytosis is the only pathway dependent on both clathrin and dynamin.
Receptor-mediated endocytosis (RME), also called clathrin-mediated endocytosis, is a process by which cells absorb metabolites, hormones, proteins – and in some cases viruses – by the inward budding of the plasma membrane (invagination).
Molecules that follow these pathways include the receptors for LDL, epidermal growth factor (EGF), and the iron transport protein transferrin. Internalization of these receptors from the plasma membrane occurs by receptor-mediated endocytosis.
While clathrin-coated endocytosis is the most efficient and dominant means of cellular cargo entry, endocytic pathways can operate without the presence of the clathrin triskelion. In the absence of clathrin in a plasma membrane, there are many elements of response that allow for the internalization of essential molecules for cellular function.
It then enters the cell by endocytosis or by making a hole in the membrane of the host cell and inserting its viral genome. [2] Schematic of different pathways of viral entry: (A) membrane fusion, (B) endocytosis, and (C) macropinocytosis Membrane fusion mediated by paramyxovirus fusion proteins. Cell entry by enveloped viruses is more complicated.
Collectively, CLICs and GEECs comprise the Cdc42-mediated CLIC/GEEC endocytic pathway, which is regulated by GRAF1. [ 1 ] [ 2 ] [ 3 ] Each of RhoA , Arf6 , or Cdc42 has the capacity to modulate one of the three distinct clathrin-independent endocytic (CIE) pathways.
AP2 adaptor complex associates with the plasma membrane and is responsible for endocytosis. [7] AP3 is responsible for protein trafficking to lysosomes and other related organelles. [8] AP4 is less well characterised. AP complexes are heterotetramers composed of two large subunits (adaptins), a medium subunit (mu) and a small subunit (sigma).
The low-density lipoprotein receptor (LDL-R) is a mosaic protein of 839 amino acids (after removal of 21-amino acid signal peptide) [5] that mediates the endocytosis of cholesterol-rich low-density lipoprotein (LDL).