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Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer occurring in about three people per million members of the population. [1] It is also known as cutaneous APUDoma, primary neuroendocrine carcinoma of the skin, primary small cell carcinoma of the skin, and trabecular carcinoma of the skin. [ 2 ]
Merkel cell carcinoma (cutaneous apudoma, primary neuroendocrine carcinoma of the skin, primary small cell carcinoma of the skin, trabecular carcinoma of the skin) Microcystic adnexal carcinoma (sclerosing sweat duct carcinoma) Micronodular basal cell carcinoma; Milia en plaque; Milium Milium; Mixed tumor (chondroid syringoma) Mucinous carcinoma
As with all skin cancers, sun exposure is a risk factor, as is a compromised immune system and previous history of skin cancer.
Telangiectasia in the legs is often related to the presence of venous reflux within underlying varicose veins. Flow abnormalities in smaller veins known as reticular veins or feeder veins under the skin can also cause spider veins to form, thereby making a recurrence of spider veins in the treated area less likely.
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Basal-cell carcinoma: Note the pearly translucency to fleshy color, tiny blood vessels on the surface, and sometimes ulceration which can be characteristics. The key term is translucency. Squamous-cell skin carcinoma: Commonly presents as a red, crusted, or scaly patch or bump. Often a very rapidly growing tumor. Malignant melanoma
Merkel cells, also known as Merkel–Ranvier cells or tactile epithelial cells, are oval-shaped mechanoreceptors essential for light touch sensation and found in the skin of vertebrates. They are abundant in highly sensitive skin like that of the fingertips in humans , and make synaptic contacts with somatosensory afferent nerve fibers .
The reasons why 20% of Merkel cell carcinoma are negative for the virus remain completely unknown but speculations include the possibility that "Merkel cell carcinoma" is actually two or more closely related cancers, only one of which is infected with MCV. Misdiagnosis of this difficult cancer may also account for some of the negative results.