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Dutasteride, sold under the brand name Avodart among others, is a medication primarily used to treat the symptoms of a benign prostatic hyperplasia (BPH), an enlarged prostate not associated with cancer. A few months may be required before benefits occur. [5] It is also used for scalp hair loss in men and as a part of hormone therapy in ...
A 2004 review comparing dutasteride and finasteride found that while finasteride was more selective in the types of 5-alpha reductase enzyme it blocked, dutasteride reduced DHT significantly more.
It may be effective in helping promote hair growth in both men and women with androgenic alopecia. [20] [21] About 40% of men experience hair regrowth after 3–6 months. [22] It is the only topical product that is FDA approved in America for androgenic hair loss. [20] However, increased hair loss has been reported. [23] [24]
Dutasteride (brand name Avodart) inhibits all three 5α-reductase isoenzymes and can decrease DHT levels by 95%. [9] [10] It can also reduce DHT levels in the prostate by 97 to 99% in men with prostate cancer. [11] [12] Epristeride (brand names Aipuliete, Chuanliu) is marketed in China for the treatment of benign prostatic hyperplasia.
Bicalutamide also shows a better safety profile than cyproterone acetate. When used as a high-dosage monotherapy, bicalutamide shows slightly inferior effectiveness in the treatment of prostate cancer compared to castration and GnRH analogues but a different and potentially superior tolerability and safety profile.
A 2004 review highlighted studies that have been done on the topic. DHEA supplements were shown to help women with adrenal insufficiency, improving depression, anxiety, mood and overall well-being.
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