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Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer occurring in about three people per million members of the population. [1] It is also known as cutaneous APUDoma, primary neuroendocrine carcinoma of the skin, primary small cell carcinoma of the skin, and trabecular carcinoma of the skin. [ 2 ]
Singer Jimmy Buffett died of Merkel cell carcinoma, a rare skin cancer, in September. Here’s what to know about the cancer, including symptoms and treatment.
Cancer Research UK has recently warned that skin cancer cases are set to rise by half by 2040
Merkel cell carcinoma accounts for fewer than 1% of all skin cancers — but when it metastasizes it often turns deadly. Skip to main content. Sign in. Mail. 24/7 Help. For premium support please ...
Basal-cell carcinoma: Note the pearly translucency to fleshy color, tiny blood vessels on the surface, and sometimes ulceration which can be characteristics. The key term is translucency. Squamous-cell skin carcinoma: Commonly presents as a red, crusted, or scaly patch or bump. Often a very rapidly growing tumor. Malignant melanoma
The reasons why 20% of Merkel cell carcinoma are negative for the virus remain completely unknown but speculations include the possibility that "Merkel cell carcinoma" is actually two or more closely related cancers, only one of which is infected with MCV. Misdiagnosis of this difficult cancer may also account for some of the negative results.
As with all skin cancers, sun exposure is a risk factor, as is a compromised immune system and previous history of skin cancer.
Merkel cells, also known as Merkel–Ranvier cells or tactile epithelial cells, are oval-shaped mechanoreceptors essential for light touch sensation and found in the skin of vertebrates. They are abundant in highly sensitive skin like that of the fingertips in humans , and make synaptic contacts with somatosensory afferent nerve fibers .