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Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer occurring in about three people per million members of the population. [1] It is also known as cutaneous APUDoma, primary neuroendocrine carcinoma of the skin, primary small cell carcinoma of the skin, and trabecular carcinoma of the skin. [ 2 ]
Singer Jimmy Buffett died of Merkel cell carcinoma, a rare skin cancer, in September. Here’s what to know about the cancer, including symptoms and treatment.
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Basal-cell carcinoma: Note the pearly translucency to fleshy color, tiny blood vessels on the surface, and sometimes ulceration which can be characteristics. The key term is translucency. Squamous-cell skin carcinoma: Commonly presents as a red, crusted, or scaly patch or bump. Often a very rapidly growing tumor. Malignant melanoma
Chiggers, a type of small mite, typically leave clusters of bites that are often very itchy. In many cases, chigger bites appear as small, red and itchy bumps. Sometimes, they can look like tiny ...
Merkel cells, also known as Merkel–Ranvier cells or tactile epithelial cells, are oval-shaped mechanoreceptors essential for light touch sensation and found in the skin of vertebrates. They are abundant in highly sensitive skin like that of the fingertips in humans , and make synaptic contacts with somatosensory afferent nerve fibers .
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SV40 has been well studied and does not cause cancer in humans, but a recently discovered analogue called Merkel cell polyomavirus has been associated with Merkel cell carcinoma, a form of skin cancer. [25] The Rb binding feature is believed to be the same between the two viruses. [25]