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In a typical set of rules, a platelet donor must weigh at least 50 kg (110 lb) and have a platelet count of at least 150 x 10 9 /L (150,000 platelets per mm³). [2] One unit has greater than 3×10 11 platelets. Therefore, it takes 2 liters of blood having a platelet count of 150,000/mm³ to produce one unit of platelets.
Platelet transfusions came into medical use in the 1950s and 1960s. [1] [5] It is on the World Health Organization's List of Essential Medicines. [6] [7] Some versions of platelets have had the white blood cells partially removed or been gamma irradiated which have specific benefits for certain populations. [8]
Typically, when platelets are isolated from whole blood, not all plasma is removed, as platelets need to be in a certain volume of plasma in order to have a clear separation from other cells. Platelet additive solution is added to bring the platelets to a concentration that sustains five to seven day storage.
They replace PMNs as the predominant cells in the wound by two days after injury. [24] The spleen contains half the body's monocytes in reserve ready to be deployed to injured tissue. [29] [30] Attracted to the wound site by growth factors released by platelets and other cells, monocytes from the bloodstream enter the area through blood vessel ...
The platelet-rich plasma (PRP) is removed from the red cells, then centrifuged at a faster setting to harvest the platelets from the plasma. In other regions of the world, the unit of whole blood is centrifuged using settings that cause the platelets to become suspended in the " buffy coat " layer, which includes the platelets and the white ...
RBC washing devices can help remove byproducts in salvaged blood such as activated cytokines, anaphylatoxins, and other waste substances that may have been collected in the reservoir suctioned from the surgical field. However, they also remove viable platelets, clotting factors, and other plasma proteins essential to whole blood and homeostasis ...
'ER' star Julianna Margulies went through medically-induced menopause at 28 years old due to fibroids treatment, she shared at the 'Women's Health' Health Lab.
Other causes of reactive thrombocythemia include: post surgery, iron deficiency, drugs, and rebound effect after bone marrow suppression. [8] Research suggests that thrombocytosis can also occur after physical exercise, and is triggered by hemoconcentration and the release of platelets from the liver, lungs and spleen. [3] [9]
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