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To make the design conform to 2NF, it is necessary to have two relations. To create these relations: Remove the functionally dependent attributes in the partial dependencies of the first normal form relation. In this example, {Manufacturer country} is the functionally dependent attribute which will be removed.
In bioinformatics, a sequence alignment is a way of arranging the sequences of DNA, RNA, or protein to identify regions of similarity that may be a consequence of functional, structural, or evolutionary relationships between the sequences. [1] Aligned sequences of nucleotide or amino acid residues are typically represented as rows within a matrix.
Multiple sequence alignment (MSA) is the process or the result of sequence alignment of three or more biological sequences, generally protein, DNA, or RNA. These alignments are used to infer evolutionary relationships via phylogenetic analysis and can highlight homologous features between sequences.
A global alignment performs an end-to-end alignment of the query sequence with the reference sequence. Ideally, this alignment technique is most suitable for closely related sequences of similar lengths. The Needleman-Wunsch algorithm is a dynamic programming technique used to conduct global alignment. Essentially, the algorithm divides the ...
Codd introduced the concept of normalization and what is now known as the first normal form (1NF) in 1970. [4] Codd went on to define the second normal form (2NF) and third normal form (3NF) in 1971, [5] and Codd and Raymond F. Boyce defined the Boyce–Codd normal form (BCNF) in 1974. [6]
More observed differences between two sequences may arise as a result of stochastic sequencing errors. Similarly, when performing assembly of a previously characterized genome, an attempt is made to align the newly sequenced DNA fragments to the existing genome sequence.
The multiple sequence alignment problem is generally based on pairwise sequence alignment and currently, for a pairwise sequence alignment problem, biologists can use a dynamic programming approach to obtain its optimal solution. However, the multiple sequence alignment problem is still one of the more challenging problems in bioinformatics.
The Smith–Waterman algorithm performs local sequence alignment; that is, for determining similar regions between two strings of nucleic acid sequences or protein sequences. Instead of looking at the entire sequence, the Smith–Waterman algorithm compares segments of all possible lengths and optimizes the similarity measure .