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Ondansetron is used off-label to treat morning sickness and hyperemesis gravidarum of pregnancy. It is typically used after other antiemetic drugs have failed. [17] A large multi-center cohort study found no association between ondansetron exposure and fetal risk compared to other antiemetics. [18]
Drugs during pregnancy and lactation: handbook of prescription drugs and comparative risk assessment. Elsevier. ISBN 978-0-444-50763-1. Schaefer C, Peters PW, Miller RK, eds. (2011). Drugs during pregnancy and lactation: treatment options and risk assessment (2nd ed.). Elsevier. ISBN 978-0-08-054977-4.
HG is estimated to affect 0.3–2.0% of pregnant women, although some sources say the figure can be as high as 3%. [6] [9] [5] While previously known as a common cause of death in pregnancy, with proper treatment this is now very rare. [13] [14] Those affected have a lower risk of miscarriage but a higher risk of premature birth. [15]
Ondansetron was approved by the U.S. Food and Drug Administration in 1991, and has since become available in several other countries, including the UK, Ireland, Australia, Canada, France and Brazil. As of 2008, ondansetron and granisetron are the only 5-HT 3 antagonists available as a generic drug in the United States. Ondansetron may be given ...
The pregnancy category of a medication is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother during pregnancy. It does not include any risks conferred by pharmaceutical agents or their metabolites in breast milk. Every drug has specific information listed in its product literature.
Specifically, it may increase the risk of birth defects, reduced growth, and early pregnancy loss. For some people, the benefits of taking Ozempic while pregnant may outweigh the risks.
Patients do receive antiemetic medications, such as Ondansetron and Dexamethasone, during the surgical procedure if the patient is at risk for it. [1] [6] Along with PONV, there are numerous complications that can happen with many different organ systems, the most threatening of which involves the respiratory system, and cardiovascular system. [5]
Holly B. Shulman is an American statistician in the Division of Reproductive Health of the Centers for Disease Control and Prevention (CDC), a developer of the Pregnancy Risk Assessment Monitoring System for the CDC, [1] and the former president of the Caucus for Women in Statistics. [2]