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Adverse drug reaction: palmoplantar erythrodysesthesia (acral erythema) Because circulating levels of estrogen increase in both cirrhosis and pregnancy, estrogen was thought to be the main cause for the increased vascularity. More recently, nitric oxide has also been implicated in the pathogenesis of palmar erythema. [5]
Chemotherapy-induced acral erythema, also known as palmar-plantar erythrodysesthesia or hand-foot syndrome is reddening, swelling, numbness and desquamation (skin sloughing or peeling) on palms of the hands and soles of the feet (and, occasionally, on the knees, elbows, and elsewhere) that can occur after chemotherapy in patients with cancer.
Cirrhosis causes a rise of estrogen due to increased conversion of androgens into estrogen. [30] Palmar erythema, a reddening of the palm below the thumb and little finger, is seen in about 23% of cirrhosis cases, and results from increased circulating estrogen levels. [31]
Palmar erythema (red palms) Weight loss. Goiter (swollen thyroid gland) ... It causes skin cells to grow rapidly and build up on the skin, causing itchy, scaly patches of thick, red skin.
Erythema (Ancient Greek: ἐρύθημα, from Greek erythros 'red') is redness of the skin or mucous membranes, caused by hyperemia (increased blood flow) in superficial capillaries. [1] It occurs with any skin injury, infection, or inflammation .
Spider angiomas are a radial array of tiny arterioles that commonly occur in pregnant women and in patients with hepatic cirrhosis and are associated with palmar erythema. In men, they are related to high estrogen levels secondary to liver disease. TEMPI syndrome; Tobacco smoking [10] Cutaneous collagenous vasculopathy
Hepatomegaly: 3 common causes, 3 rarer causes. Common are 3 C's: Cirrhosis ... Encephalopathy / palmar Erythema Foetor hepaticus Gynaecomastia Hepatomegaly
Palmar xanthoma is clinically characterized by yellowish plaques that involve the palms and flexural surfaces of the fingers. [ 2 ] : 531 Palmar xanthomas are characterised by yellowish to orange, flat macules or slightly elevated plaques, often with a central white area which may be localised or generalised.