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The anti-oxidants and zinc supplements only reduced the risk of progression to wet macular degeneration. Those that benefited from the dietary supplements included those with intermediate-stage AMD and those with advanced AMD in one eye only. The supplements had no significant effect on the development or progression of cataracts.
In the late 1990’s squalamine was discovered to exhibit antiangiogenic activity, [12] [13] and as a consequence was later studied in several early stage clinical trials for both cancer, [14] [15] age related macular degeneration, administered intravenously, [16] [17] and as an eye-drop in combination with intraocular ranibizumab.
Age-Related Macular Degeneration is a degenerative maculopathy associated with progressive sight loss. It is characterised by changes in pigmentation in the Retinal Pigment Epithelium, the appearance of drusen on the retina of the eye and choroidal neovascularization. AMD has two forms; 'dry' or atrophic/non-exudative AMD, and 'wet' or ...
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BrightFocus Foundation is a nonprofit organization based in Clarksburg, Maryland.BrightFocus funds research in an effort to discover cures for Alzheimer's disease, macular degeneration and glaucoma, and provides information and free English and Spanish resources to increase awareness about these diseases.