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The gastric folds (or gastric rugae) are coiled sections of tissue that exist in the mucosal and submucosal layers of the stomach. [1] They provide elasticity by allowing the stomach to expand when a bolus enters it. These folds stretch outward through the action of mechanoreceptors, which respond to the increase in pressure. [2]
The gastrointestinal wall of the gastrointestinal tract is made up of four layers of specialised tissue. From the inner cavity of the gut (the lumen ) outwards, these are the mucosa , the submucosa , the muscular layer and the serosa or adventitia .
Rugae folds behind the anterior teeth in the hard palate of the mouth. In anatomy, rugae (sg.: ruga) are a series of ridges produced by folding of the wall of an organ. [1]In general, rugae are a biological feature found in many organisms, serving purposes such as increasing surface area, flexibility, or structural support.
The inner part of the stomach wall is the gastric mucosa a mucous membrane that forms the lining of the stomach. the membrane consists of an outer layer of columnar epithelium, a lamina propria, and a thin layer of smooth muscle called the muscularis mucosa. Beneath the mucosa lies the submucosa, consisting of fibrous connective tissue. [17]
The epithelial lining of the gland ducts is of the same character and is continuous with the general epithelial lining of the stomach. The sodium-iodide symporter (SIP) is expressed in all the surface mucous cells (at the basolateral membrane) but not in the mucous neck cells.
The stomach is a distensible organ and can normally expand to hold about one litre of food. [22] This expansion is enabled by a series of gastric folds in the inner walls of the stomach. The stomach of a newborn baby will only be able to expand to retain about 30 ml.
The mucus allows the acid at pH above 4 to penetrate lining, but below pH 4 (i.e. when acid is more concentrated) the acid cannot penetrate the mucus. This is called viscous fingering. [ 6 ] Thus the foveolar cells can pump out a lot of acid, but acid once in the lumen of the stomach is prevented from returning.
These are known as non-ciliated columnar epithelium. Non-ciliated simple columnar epithelium is made up of glandular goblet cells which secrete mucin to form mucus. [1] The rest of the cell is made up of cytoplasm with membrane bound secretory granules which secrete the mucin, and are found towards the apical surface of the cell. [1]